Tablet Presentation

Each prolonged release tablet contains:
Mesalazine IP 500 mg

• Mesalazine is the 5- amino salicylic acid and is the active moiety of the sulphasalazine.
• It is used in the condition of inflammatory bowel disease and ulcerative colitis.

Indication

• Ulcerative colitis
• Crohn’s disease
• In inflammatory bowel disease
• proctitis

Mechanism of action

It acts by blocking the nuclear factor kappa B receptor which is responsible for the production of the inflammatory cytokines

Also it acts by blocking the cyclooxygenase enzyme and prostaglandins synthesis

Pharmacokinetic

Absorption- It is absorbed orally
Protein binding – It is about 43% bound to serum proteins
Metabolism – It is metabolized in the liver to N- acetylsalicylic acid
Excretion- It is excreted by urine

Side effects

• Itchiness
• Headache
• Rash
• Fever

Contraindication

• Contraindicated in pregnant
• Contraindicated in people with known hypersensitivity
• Contraindicated in renal disease

Storage

Store it at room temperature